Can nano CBD be absorbed into the bloodstream faster than conventional CBD?
It is evident that the CBD industry is constantly expanding its boundaries, and this time it’s with CBD nanotechnology. It is regarded as the latest buzzword. Many claims to have the advantages that nano CBD can bring, whereas others believe it’s an urban legend. Nano CBD is the most recent method to enhance the absorption rate of CBD into the bloodstream.
What does the research tell us? Does it make sense for nano CBD to get into your bloodstream in a larger quantity than regular CBD? In addition, is it safe to use nano CBD?
What is Nano CBD?
Nanotechnology uses “tiny things” between 1 and 100 nanometers at the nanoscale. Nanotechnology is a common feature in medicine, cosmetics, robotics, and biomaterials and is now being used in organic compounds like CBD.
Certain companies describe nano CBD as “water-soluble CBD” — however, this isn’t accurate. It’s not true that CBD is water-soluble; it’s simply that the smaller molecules allow them to appear to be water-soluble at a macro scale. We’ll go into how this happens in greater detail in the future.
The Bioavailability of CBD
If you’ve been a CBD enthusiast for some time now, you know that CBD has a very low bioavailability.
How do I define bioavailability? The bioavailability of an element is the amount and the degree to which it is absorbed into the bloodstream and produces an active action.
The bioavailability rate of a substance depends on many factors, such as its method of intake. For instance, the oral form of CBD has a bioavailability rate of 20 per cent and a low rate of 4 per cent. So if you take 100 milligrams of CBD, just 20% (20 milligrams) will get into the bloodstream and cause an active effect 1.
Vaporized consumption has the highest bioavailability rates, between 34 and 46% .
Oral consumption is deficient, and vaporized consumption is so heavy in the lung area users seek an alternative. To some, it’s nano CBD.
Why Would Nano CBD Work Better Than Regular CBD?
The reason CBD producers and consumers began to become attracted to nano CBD is due to the nature of the substance itself. CBD is a molecule that is hydrophobic, which means it can’t mix with water.
They are also hydrophobic; CBD cannabinoids, such as CBD, have a lipophilic component. This means they mix or dissolve in fats, lipids, or lipids. Thus, CBD molecules aren’t able to bond naturally to water molecules. This is the reason why bioavailability is extremely low.
Consider the situation this way, your digestive tract and mouth are watery. Therefore, CBD can be described as oily. Because oil and water don’t mix, most CBD particles are hidden within droplets until fully digested.
Furthermore, due to the “first-pass metabolism,” the majority of CBD From the gods that is swallowed gets broken down and processed in the intestinal tract. When all the processes are complete, only a small amount of CBD remains to be absorbed into the bloodstream.
However, once the CBD particles shrink to a size (nano) and look and behave like an insoluble substance. This is why they’re known as “water-soluble CBD,” a term only employed for marketing purposes. CBD isn’t going to shed its hydrophobic characteristics to be water-soluble. CBD still follows the pathway of fat absorption but is released as tiny particles.
It’s much easier for the human body to absorb and digest the nutrients from oil that have been broken down into tiny drops. Smaller bubbles have a more significant surface contact with body enzymes and spongy tissue. This helps the body to absorb CBD molecules faster.
CBD requires further processing by the body to be fully distributed into the bloodstream, in contrast to the water-soluble molecules, which the body can utilize in a matter of minutes.
The study, released in the European Journal of Pharmaceutics and Biopharmaceutics, examined the efficacy of cannabinoid substances when they are encapsulated. Researchers employed a technique to encapsulate cannabinoid compounds in nanostructured carriers of lipids (NLCs).
Nanostructured Lipid carriers (NLCs) are a smarter drug carrier system consisting of biodegradable, physiological and biocompatible lipid materials. NLCs are used in medicinal applications that require a variety of delivery of drugs, such as oral or topical, ocular, and more.
This carrier system provides numerous routes for administration and can offer high therapeutic efficacy and security for drugs that are more difficult to deliver.
Researchers have discovered that ” NLC recovery, morphology, dimensional distribution and encapsulation efficiency are presented.” This implies that CBD particles more petite in size are absorbed into the bloodstream more effectively than larger CBD particles [4].
What The Research Says About Nano CBD
When properly produced, If it is made correctly, nano CBD oil can boost the amount of CBD which enters the bloodstream. While there’s not much research on the subject, this is what the study has to say about nano CBD.
A promising study from 2018 published in The Journal of Pharmaceutical Sciences looked at the bioavailability and bioavailability of Sativex compared to an emulsion of CBD/THC in men who are healthy. The study’s researchers observed an increase in the overall absorption of the nanoemulsion .
A study from 2017 released in The Journal of Controlled Release compared the bioavailability of CBD/THC Piperine nanoemulsion using Sativex, a THC/CBD-approved oromucosal spray, on healthy subjects.
The study demonstrated significant increases in absorbance from THC and CBD compared to Sativex However, it must be mentioned that the nanoemulsion contained Piperine -a natural absorption enhancer.
A 2016 study published by The Journal of Drug Development and Industrial Pharmacy focused on using lipid nanoparticles to deliver cannabinoids.
The study was focused on developing an oral delivery vehicle that is effective for the cannabinoid-derived derivative CB13. According to the study’s authors, the derivative has a therapeutic option for chronic pain conditions that are not responding well to traditional analgesics. In addition, the lipid formulation utilized in this study was a viable vehicle for the oral delivery of the compound.
This implies that nanoparticles are a great source of cannabinoid delivery to targeted tissues and can help sufferers who don’t respond to traditional treatments.
What Are the Risks of Nano CBD?
Nano CBD holds promise, but there’s plenty of research to be done, particularly regarding the safety of these products.
Professor. Pratap Singh, assistant professor at the University of British Columbia, declared that Nano-encapsulation “should require more clinical trials” and “more rigorous testing if the size is below 50 or 20 nanometer’s warning was given because nanoparticles could enter human cells and be absorbed by different organs, leading to tissue injury and inflammation.
A report on nanotechnology from the Organization for Economic Co-operation and Development (OECD) examined the benefits and risks of using nanotechnology for pregnancy.
The report states, “it is unclear whether nanoparticles can pass from a pregnant woman’s body via the placenta into the unborn child.”
When particles shrink by a size, smaller particles begin to behave similarly to larger particles. But, as they get smaller, down to 100 nanometers and exhibit some characteristics that are different from average particle sizes, like passing through gaps that they could not traverse before and even reaching tissues that were not anticipated.
The tiny particles can get into various types of tissues and those they target.
However, Dr Singh advised consumers to be more cautious about whether the product is safe to use and safe instead of whether it contains nanoparticles.
Summary: Is Nano CBD More Effective Than Regular CBD?
Research is limited but promising: nano CBD is absorbed by the body more efficiently.
To the consumer, this means that they will get more excellent value from their use of nano CBD. There is space for further study, and CBD users must be cautious when selecting the right”nano” CBD brand. There’s still a chance of risks associated with nano CBD — however, it is impossible to know until we conduct more studies.
CBD brands that offer nano CBD products are known to over-promise to sell their products. Therefore, look for a brand that provides strict third-party testing and is up-to-date with the latest research on the nano CBD sector.
